ologicaldialysateandimproveultrafitrationthroughdecreasingperitonealtiuehydraulicconductivity.althoughapreviousshortreportshowedthatrepeateduseofhyaluronanincreaseperitonealfluidremoval,thedetailedchangeinperitonealtraortcharacteristicsafterrepeateduseofhyaluronaninperitonealcavityisstillnotknow.inaddition,althoughtheperitonealsurfactantlayerwasindirectlyestablishedbytheresearchofhumanperitonealmesothelialcells(hpmcs),therewasnotanymorphologicalevidenceofit.
recentstudieshaveshownthatperitonealmesothelialcellscouldsynthesizela
rgeamountofhyaluronanandthenewlysynthesizedpolymermayformapericellularhyaluronancoattoprotectthecellsfromdamage.recently,threerelatedmammaliangeneshavebeenidentifiedashasynthases,designatedhas-1,has-2andhas-3,andtheenzymesofthesethreegenesdilayhomologyinmolecularstructureandaminoacidsequence.allofthemcancatalyzethesynthesisofhyaluronanattheierfaceoftheplasmamembrane.thenewlysynthesizedpolymerextrudedthroughthemembrane,whereitcanformpericellularcoatbybindingwithotherpolymersorhyaluronanbindingprotein.whichhyaluronansynthaseisthecriticalenzymetocatalyzehyaluronanandformpericellularcoats?howdoinflammationmediatorsandosmoticagentsmodulatehyaluronansynthasesexpreioninhpmcs?asweknow,hyaluronanwithdifferentmolecularweighthasdifferentfunction.howdoeshyaluronanwithdifferentweightaffectthehyaluronansynthasesexpreion?inordertosolvetheproblemswedesignedthefollowingstudies.
1.hyaluronanpreservesthemembranetraortpropertiesinchronicperitonealdialysisan
上一页 [1] [2] [3] [4] [5] [6] [7] [8] [9] [10] ... 下一页 >>