mol/l),葡聚糖(5)及90mmol/l甘露

醇都促进人腹膜间皮细胞透明质酸合成。高浓度葡萄糖促进ha合成的作用最为明显，其同时促进has-2和has-3mrna的表达。与高浓度葡萄糖相比，葡聚糖促进ha合成的作用较弱，其对has-3mrna没有影响，主要促进大分子透明质酸的合成，因而更接近hpmcs的生理状态。这一作用与各组间渗透压差可能无关。
6.lha和hha均促进hpmcshas-2mrna表达，lha对has-3mrna表达也有增强作用，而hha则没有这一作用。因此，从选择腹膜保护剂的角度分析，我们倾向于选择更具生物相容性hmw-ha。
themechanismofhyaluronaninperitonealdialysis
peritonealdialysis(pd)isanestablishedformofrenalreplacementtherapy.ultrafiltrationfailureisanimportantreasonofinadequacyandfailureofpdandtheresearchtopreventthedecreaseofultrafiltrationandmaintaintheperitonealfunctioninlong-termperitonealdialysisisalwaysthehototofpd.hyaluronanisalongpolysaccharidechainthatismadeupofrepeatingdisaccharideunitsofn-acetylglucosamineandglucuronicacid.wehaverecentlyshownthatadditionofhyaluronaninanacuteratmodelofpdcoulddecreasetheperitonealfluidaorptionrateandimprovethenetultrafiltrationvolume.thiseffectisbothconcentrationandmolecularweightdependent.themechanismofhyaluronanisnotclear.ithasbeensuosedlongagothattherewasasurfactantlayeronperitoneumandthislayermayplayimportantroleinperitonealtraort,eeciallyonperitonealfluidtraort.vibrationcandestroythislayerandincreasetheperitonealtraortrate.wesuectinlong-termperitonealdialysisthislayermaybewashedoffandtheloofthishydrophobiclayermightleadtotheincreaseoftheperitonealfluidaorptionandthedecreaseofultrafiltration.theaddedexogenoushyaluronanmightaccumulateonperitonealsurfaceandformarestrictivefilter“cake”withendogenoushyaluronan,whichmightprotecttheperitoneumfromun-physi

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